Gene Set Enrichment Analysis (GSEA) showed that a variety of cancer-promoting pathways including HEDGEHOG_ SIGNALING and WNT_BETA_CATENIN_ SIGNALING were significantly enriched in the FBXO2 high expression group from TCGA OV cancer database (Fig. 3A), suggesting a cancer-promoting role of FBXO2. Here, FBXO2 is linked to cancer.