Symptoms and signs may be due to compression of adjacent anatomical structures (e.g., superior extension compressing the optic chiasm with resultant visual loss) and syndromes associated with hormone excess [e.g., growth hormone (GH) in acromegaly; ACTH in Cushing Disease; thyroid-stimulating hormone (TSH) in thyrotropinomas (TSHomas)] or insufficiency due to failure of the normal pituitary gland (hypopituitarism) [2]. The gene discussed is GH1; the disease is hypopituitarism.