For example, circASAP1 promoted HCC growth and pulmonary metastasis by enhancing the expression of MAPK1 and CSF-1 via sponging miR-326 and miR-532-5p [9], while circDLC1 inhibited HCC development and progression via circDLC1-HuR-MMP1 axis, serving as a potential therapeutic target for HCC [10]. The gene discussed is MAPK1; the disease is hepatocellular carcinoma.