Moreover, the TUNEL staining (green fluorescence, Supplementary Fig. 6A), Bax (red fluorescence, Supplementary Fig. 6B), Bcl-2 (yellow fluorescence, Supplementary Fig. 6C) and Caspase-3 staining (pink fluorescence, Supplementary Fig. 6D) of tumor tissue sections all showed that PAE-siRNA induced more apoptosis in most cells. Here, BCL2 is linked to neoplasm.