Although genetic studies from our and other groups have identified multiple prognostic genes associated with prostate cancer progression, including aldehyde oxidase 1 [56], solute carrier family 35 member B4 [20], and carboxylesterase 1 [57]; however, to our knowledge, this is the first study to link TNFRSF13B to prostate cancer. This evidence concerns the gene TNFRSF13B and Familial prostate cancer.