A recent study demonstrated that silencing TNFRSF13B led to a significantly increased death in breast cancer cells through inhibiting anti-apoptotic/pro-survival mediators, TNF receptor superfamily member 1B, BCL2 apoptosis regulator, and RELA proto-oncogene NF-KB subunit, along with cell cycle arrest through inducing cyclin D2 and proliferating cell nuclear antigen [53]. The gene discussed is PCNA; the disease is breast cancer.