To further elucidate the molecular mechanisms underlying the effects of TNFRSF13B in regulating the growth of prostate cancer cells, the differentially expressed genes between control- and shTNFRSF13B-transfected PC-3 and 22Rv1 cells were analysed by microarray gene expression profiling. The gene discussed is TNFRSF13B; the disease is prostate carcinoma.