Using a combination of lipidomics, transcriptomics, bioinformatics, RT-qPCR, in vitro cleavage assays and imaging we demonstrated that DGAT2 mRNA is a RIDD substrate and that its regulation by IRE1α has functional consequences for TAGs synthesis, their incorporation into lipid droplets and adaptation of cancer cells to nutritional stress. This evidence concerns the gene DGAT2 and cancer.