Additionally, loss of Nedd9 markedly decreased CLL cell migration in transwell assays, reducing both migration of CLL cells towards FBS as a mixture of chemoattractants (Fig. 4C, left), and directed chemotaxis towards CXCL12 that induced massive migration of CLL cells (Fig. 4C, right) [8, 24]. Here, CXCL12 is linked to B-cell chronic lymphocytic leukemia.