NEDD9 expression in CLL lymph nodes was accentuated in proliferation centers for a subgroup of CLL patients (33%, n = 7); for 38% of patients, there was a diffuse pattern of NEDD9 expression in CLL infiltrating cells (n = 8), while there was negative staining in 28% (n = 6) of the cases (Fig. 5F, Table S1). Here, NEDD9 is linked to B-cell chronic lymphocytic leukemia.