Using the Eμ-TCL1 mouse model [17, 18], we generated TCL1tg/wtNedd9wt/wt and TCL1tg/wtNedd9−/− [16] cohorts (designated TCL1 and TCL1-N mice, respectively) to analyze the consequence of constitutive Nedd9 depletion for CLL pathogenesis. Here, NEDD9 is linked to B-cell chronic lymphocytic leukemia.