NEDD9 and B-cell chronic lymphocytic leukemia: We crossed those mice to TCL1 mice generating cohorts of CLL mice with and without Nedd9 loss in the B-cell compartment, designated TC-N (TCL1tg/wtCD19Cretg/wtNedd9flfl) and TC mice (TCL1tg/wtCD19Crewt/wtNedd9flfl), respectively (Fig. 2A, B).