Although Nedd9 phosphorylation was induced in the TCL1 CLL cell within 10 min of BCR stimulation, Nedd9 deletion did not affect either baseline or anti-IgM-induced expression and phosphorylation of BCR downstream targets such as ERK1/2 and AKT (Fig. 3D, E), and could be confirmed by longer-time dynamics of BCR stimulation in additional pools of CLL cells (Fig. S2D). Here, CD40LG is linked to B-cell chronic lymphocytic leukemia.