Notwithstanding, inhibition of AURKA and HDAC6 or their combination could not fully recapitulate the migratory defect to the extent of Nedd9-knockout murine CLL cells, indicating that NEDD9 also has additional functions beyond the AURKA/HDAC6 signaling pathways. The gene discussed is NEDD9; the disease is B-cell chronic lymphocytic leukemia.