NEDD9 and B-cell chronic lymphocytic leukemia: Although we could not find a correlation between NEDD9 expression in peripheral CLL cells and bulky disease of CLL8 patients (Table 1), we discovered a strong positive correlation between NEDD9 levels (above/below median) and leukocyte count – a hallmark of CLL aggressiveness (Table 1), further implying a functional role for NEDD9 in CLL pathogenesis.