As measured by the Seahorse XF Mito Stress Test from available peripheral blood lymphocytes samples from the small subgroup (n = 6 from the larger cohort of 12 RA participants), there were no significant mean changes in isolated RA CD4 + T cell oxidative (oxygen consumption rate (OCR); ρmol/min) (Fig. 1B-D) or basal glycolytic (extracellular acidification rate (ECAR); mpH/min) metabolism following HIIT (Supplemental Fig. 1). This evidence concerns the gene CD4 and rheumatoid arthritis.