Interestingly, we also found that GRN was expressed in TAMs in RB (Fig. S11A), and the expression of GRN was positively correlated with the expression of angiogenesis-related genes (p = 0.0002, r = 0.313, Pearson correlation, Table S5, Fig. S11B), indicating the ability of TAM to promote angiogenesis through GRN expression in RB. This evidence concerns the gene GRN and retinoblastoma.