E2F8 and cancer: In addition to TAMs and astrocyte-like cells, we found that CAFs were characterized by highly expressed cell proliferation-related genes, such as PLK2, ATF3, SNHG12, HJURP, E2F8, and EXO1 (Fig. S10A), and significantly enriched by many cell proliferation and cancer-related functions in CAFs, such as cell cycle, DNA replication, DNA damage and p53 signaling pathway (Fig. S10B, C).