Based on inferred CNV profiling from the retina and RB scRNA-seq datasets, we found different types of CNVs in the RB tumor samples (Fig. 2C), including gain of chromosome (Chr) 6p (Samples: RB05 and RB06), gain of Chr1q and loss of Chr16q (RB02, RB03, RB04, and RB07), and gain of Chr7 and losses of Chr3, 8, 10 (RB01). This evidence concerns the gene RB1 and retinoblastoma.