Elevated Crmp1 phosphorylation in the spinal cord of SOD1G93A mice may be explained by the fact that Sema3A signaling hyperactivates the complex of Cdk5 and p25, an activator of Cdk5, in the brain and spinal cord in a mouse model of ALS as well as in ALS patients (Nguyen et al., 2001; Klinman and Holzbaur, 2015; Bk et al., 2019). This evidence concerns the gene CDK5 and amyotrophic lateral sclerosis.