Moreover, elevation of both Crmp4 and Crmp4-dynein complex leads to neuronal death in ALS model mice (Duplan et al., 2010; Maimon et al., 2021) while the inhibition of Crmp2 phosphorylation ameliorates the motor phenotype of SOD1G93A mice (Numata-Uematsu et al., 2019). Here, DPYSL2 is linked to amyotrophic lateral sclerosis.