SCN1A and epilepsy: The epilepsy, comorbidities, and high mortality exhibited by DS patients are recapitulated in genetically engineered animal models of SCN1A disruption, including rat (Mashimo et al., 2010), mouse (Yu et al., 2006; Mistry et al., 2014), zebrafish (Baraban et al., 2013), and Drosophila (L. Sun et al., 2012).