In particular,2-AG exerted its analgesic effect by stimulating CB2 receptors; therefore,MAGL modulation may influence pain.13 MAGLinhibition has been shown to alleviate allodynia in some neuropathicpain models.14−16 Thus, MAGL represents a feasible and promising therapeutictarget for the treatment of neurodegenerative diseases, inflammation,pain, and cancer.17 This evidence concerns the gene MGLL and neurodegenerative disease.