Our results show that LAML had a relatively high mutation level, with RUNX1 alterations exceeding 13% with “mutation” as the primary type; the hot spot mutation of RUNX1 was D96Gfs*15/Gfs*11/Mfs*10 in the Runt domain, which occurred in nine cancers (LAML and BRCA) in nine patients and resulted in a truncated protein (Figure 10A–10C). Here, RUNX1 is linked to cancer.