To determine the effects of IL-6/STAT3 signals in fibrosis of MI, the IL-6 OE lentivirus were used to specifically active STAT3 (Phosphorylated form) in heart, and the results showed that over expression of IL-6 could increase the fibrotic areas after MI and shown in Figure 6A. The gene discussed is STAT3; the disease is myocardial infarction.