Echocardiographic measurements demonstrated that mice in PTX3-KD group had lower LVAWd, LVAWs, ES and FS, but higher LVIDd and LVIDs compared with those in model group, as well as PTX3-KD improved the E and A peak rate, PVA, PVD, PVS compared with Model-group (Figure 2B), indicating the PTX3-KD Successfully improved the systolic and diastolic function of the heart of murine HF after MI. The gene discussed is PTX3; the disease is myocardial infarction.