PTX3 and myocardial infarction: The relative proteins of IL-6 and phosphorylated STAT3 (p-STAT3) as well as fibrosis associated proteins: collagen I/III were tested by western blot and our results showed the over expression of IL-6 could significantly aggravate and promote the expression of IL-6, p-STAT3 as well as collagen-I/III, shown in Figure 6B, these results intensely indicated the IL-6/ STAT3 signal plays the pivotal roles in fibrosis of MI in hearts, and PTX3’ roles on IL-6/STAT3 signals could effectively influence the progression of fibrosis in MI.