The endocrine disruptors of air pollutants can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway and contributing to infertility (De Coster and van Larebeke 2012). The gene discussed is ESR1; the disease is Infertility.