In lung cancer, Tp53 loss and Kras activation lead to elevated levels of the receptor for advanced glycation end products (RAGE) within blood, which educates distant osteoblasts to stimulate the expansion of long-lived pro-tumorigenic SiglecFhi neutrophils (in contrast, SiglecFlo neutrophils are enriched in healthy lung; Engblom et al., 2017; Pfirschke et al., 2020). Here, AGER is linked to lung cancer.