MUC4 provides steric hindrance via its bulky, glycosylated extracellular region to mask immune cell surface antigens and shield tumor cells from immune recognition, thus enhancing survival and extravasation of metastasized tumor cells via interaction with macrophages and hematopoietic progenitors (Rowson-Hodel et al., 2018). This evidence concerns the gene MUC4 and neoplasm.