Studies have shown that Salmonella can downregulate the expression of PD‐L1 in the tumor cells and inhibit tumor growth, which is related to the levels of the phosphorylated protein kinase B (p‐AKT), phosphorylated mammalian target of rapamycin (p‐mTOR), and phosphorylated p70 ribosomal S6 kinase (p‐p70S6K).72 The gene discussed is CD274; the disease is neoplasm.