DSG2 could also identified early-stage ESCC with a similar AUC value of 0.715 (95% CI: 0.584–0.847), a sensitivity of 36.3% (95% CI: 12.4–68.4%), and a specificity of 84.8% (95% CI: 75.4–91.1%). Here, DSG2 is linked to esophageal squamous cell carcinoma.