FUT2 and type 1 diabetes mellitus: Although an association between FUT2 non-secretor status and T1D was reported in Caucasian and Japanese population samples [78,79], and children carrying the high-risk HLA genotype that are homozygous FUT2 non-secretors showed predisposition to rapid disease progression [80], the actual role of FUT2 gene variants in T1D is still disputed [71].