AIRE and autoimmune polyendocrine syndrome type 1: Four AIRE mutations have been shown to commonly occur in APS-1 patients and these are p.(Arg257Ter) in Finnish, German, Swiss, British, and Northern Italian families; p.(Arg139Ter) in Sardinian families; p.(Tyr85Cys) in Iranian Jewish families; and a 13-bp deletion in exon 8 in British, Dutch, German, and Finnish families (12, 13, 14).