AIRE and hypoparathyroidism: An analysis of probands with suspected familial hypoparathyroidism showed that the five probands harbouring AIRE mutations all had apparently isolated hypoparathyroidism and were significantly younger than the AIRE mutation-negative probands (mean ± s.d. age of 11.8 ± 2.6 vs 20.6 ± 20.3 years, P  < 0.001) (Table 1 and Supplementary Table 2).