The pooled results showed that the prevalence of PTCI was statistically significantly associated with six factors: pupillary dilation (OR = 4.17, 95% CI = 1.92–9.06), traumatic subarachnoid hemorrhage (SAH) (OR = 3.51, 95% CI = 1.41–8.72), abnormal prothrombin time (PT) (OR = 5.01, 95% CI = 3.23–7.77), hematoma location (OR = 20.27, 95% CI = 5.24–78.42), and hematoma volume (OR = 8.07, 95% CI = 2.86–22.76), while lower Glasgow Coma Scale (GCS) score (OR, 0.33; 95% CI, 0.14–0.77; I2 = 99.2%) is a protected risk for PTCI. The gene discussed is F2; the disease is hematoma.