TP53 and non-small cell lung carcinoma: Hanai et al. [32] applied ANNs to construct a prognostic model for 125 NSCLC patients with 12 clinico-pathological variables (age, sex, smoking index, tumor size, p factor, pT, pN, stage, histology) and 5 immunohistochemical variables (p27 percentage, p27 intensity, p53, cyclin D1, retinoblastoma).