L3MBTL2 and neoplasm: Lethal-3-malignant brain tumor-like 2 (L3MBTL2) is an essential member of the Polycomb group proteins (PcG), and it belongs to the family of Malignant brain tumor (MBT) proteins that are associated with modification of the chromatin structure by binding to histones, which results in compaction of the chromatin (Bonasio et al., 2010; Qin et al., 2012; Trojer et al., 2007; Ogawa et al., 2002).