As exemplified in the study by Ota et al., Sirtinol induces senescence-like growth arrest in MCF-7 and H1299 cell lines.37 The structural optimization of the linker (red mark in Fig. 4) in the Sirtinol structure led to the discovery of Salermide (19, Fig. 4).38 Compared to Sirtinol, Salermide has similar inhibitory activity against SIRT2, and higher anti-proliferative activity and apoptosis induction properties in a panel of cancer cell lines. The gene discussed is SIRT2; the disease is cancer.