The thiazolidinediones, a class of heterocyclic compounds consisting of a five-membered C3NS ring, usually refers to a family of drugs used in the treatment of diabetes mellitus type 2.8 Rosiglitazone is an antidiabetic drug which activates peroxisome proliferator-activated receptor γ (PPARγ) in the thiazolidinedione class.9 It works as an insulin sensitizer through binding to the PPARγ in fat cells and making the cells more responsive to insulin. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.