The thiazolidinediones, a class of heterocyclic compounds consisting of a five-membered C3NS ring, usually refers to a family of drugs used in the treatment of diabetes mellitus type 2.8 Rosiglitazone is an antidiabetic drug which activates peroxisome proliferator-activated receptor γ (PPARγ) in the thiazolidinedione class.9 It works as an insulin sensitizer through binding to the PPARγ in fat cells and making the cells more responsive to insulin. This evidence concerns the gene PPARG and diabetes mellitus.