ALB and cancer: The assembled HSA-NPs exhibits enhanced permeability and retention effect (EPR effect), hence, it enables too passive tumor targeting in cancer therapy.8 Additionally, albumin molecules possess many functional groups which helps them in binding to the surface of other bio-active ligands, such as different amino acids found in human blood.7,9 Hence, it is necessary to study the interaction ability of HSA towards NPs as they may be a key for many bio-medical issues.