FN1 and intrahepatic cholangiocarcinoma: In comparison to 2D cell platforms, three-dimensional (3D) ICC scaffolds culture environment and the presence of extracellular matrix (ECM) proteins (collagen type I or fibronectin), especially the fibronectin, facilitate hepatocyte viability and maintenance of the liver-specific phenotype in vitro, and enable prediction of hepatotoxicity caused by diclofenac.