STAT3 and lung carcinoma: Our results showed that the curcumol targets the other cell cycle gatekeeper kinases, such as cyclin-dependent kinase 1 (CDK1); CDK1 is a potential prognostic biomarker of/and target for lung cancer (51); CDK1 activity is critical for JAK/STAT3 signaling activation, and the inhibition of CDK1 can suppress lung cancer (52).