Furthermore, fat-mediated alterations of the gut microbiota link bile acid metabolism to CRC since changes in the gut microbiota may promote an altered overall bile acid pool, which activates or restricts intestinal and hepatic cross-signaling of the bile acid receptor, farnesoid X receptor (FXR), which plays a crucial role in regulating intestinal cell proliferation and carcinogenesis (26, 27). Here, NR1H4 is linked to colorectal carcinoma.