SIX1 and pulmonary fibrosis: For instance, the decreased expression of miR-221 has been found in human idiopathic pulmonary fibrosis (IPF) tissues, and overexpression of miR-221 could inhibit bleomycin (BLM)-induced pulmonary fibrosis through the TGF-β1/Smad3 signaling pathway.9 The miR-200 family target ZEB1 and the miR-205 family target SIP1 to regulate EMT in tumor progression.13 MiR-448-5p inhibits TGF-β1-induced EMT and pulmonary fibrosis by targeting Six1.14 MiR-29c attenuates pulmonary fibrosis by regulating epithelial cell renewal and apoptosis.15