In a retrospective study of adult obese male patients with uncontrolled type 2 diabetes mellitus, who complained of mild to moderate erectile dysfunction, the authors investigated the contribution of body weight and glycemic control to the reversibility of hypogonadism to eugonadism under different glucose-lowering medications, including GLP1-RAs such as liraglutide and dulaglutide. This evidence concerns the gene GLP1R and hypogonadism.