In addition, JPHYD significantly inhibited the expression of miR21-5p and the protein levels of Smad3, Vimentin, Snail, and N-cadherin, while E-cadherin and Smad7 proteins increased in tumor tissues treated with JPHYD (Figures 6(f) and 6(g)). The gene discussed is SMAD7; the disease is neoplasm.