In this study, we analyzed the expression of RAPGEF2 gene and eight RAPGEF2-associated genes (SORBS2, SMARCAD1, ZNF148, AKAP13, PIK3R1, ARID1A, CTSO, and GNE) in HCC sample and investigated their relationship with OS of HCC patients and the immunotherapy response using TCGA and ICGC databases. This evidence concerns the gene PIK3R1 and hepatocellular carcinoma.