PLK1 and Familial prostate cancer: We find that MBNL1-AS1 has been reported to inhibit the progression of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling [42] and PTEN signaling happens to be regulated by PLK1, PAF, YB-1, TWIST, YY1, KLF4, and SALL4 [43–48].