It is known that the body weight loss, feed intake and the increase in the organ index are considered to be the classical characteristics in T2DM induced by a high-fat diet and STZ administration.36,37 The increased kidney index in DN indicates the development of renal hypertrophy.38 The results indicate that SPP can ameliorate the decrease in body weight and kidney index seen in diabetic mice, and SPP treatment showed a significant effect on daily food and water intake. This evidence concerns the gene HM13 and type 2 diabetes mellitus.