Alzheimer’s Disease (AD) is a notable example: a decade ago it was shown in a mouse model of AD that AQP4 was conspicuously absent from endfeet adjoining amyloid plaques (Yang et al., 2011), while more recent studies have demonstrated reduced amyloid clearance following targeted disruption of Aqp4 (Iliff et al., 2012; Xu et al., 2015; Smith et al., 2019; Rosu et al., 2020). Here, AQP4 is linked to Alzheimer disease.