AQP4 and early-onset autosomal dominant Alzheimer disease: Furthermore, mislocalization and altered expression of AQP4 is a common denominator in a variety of neurological conditions, ranging from stroke to mesial temporal lobe epilepsy and Alzheimer’s disease (Eid et al., 2005; Frydenlund et al., 2006; Yang et al., 2011; Kitchen et al., 2020).