Alzheimer’s Disease (AD) is a notable example: a decade ago it was shown in a mouse model of AD that AQP4 was conspicuously absent from endfeet adjoining amyloid plaques (Yang et al., 2011), while more recent studies have demonstrated reduced amyloid clearance following targeted disruption of Aqp4 (Iliff et al., 2012; Xu et al., 2015; Smith et al., 2019; Rosu et al., 2020). The gene discussed is AQP4; the disease is early-onset autosomal dominant Alzheimer disease.