Moreover, TRPV1 may tonically modulate emotional defensive responses such as anxiety, fear and panic (Millan, 2003; Mcnaughton and Corr, 2004; Terzian et al., 2009; Canteras et al., 2010; Casarotto et al., 2012; Aguiar et al., 2015; Gobira et al., 2017). Here, TRPV1 is linked to Anxiety.