Moreover, TRPV1 likely modulates anxiety, fear and panic responses in vivo (Almeida-Santos et al., 2013; Aguiar et al., 2014; Terzian et al., 2014) and also the severity of neurological and cognitive disorders, including epilepsy, depression and Alzheimer’s Disease (Chen et al., 2017; Balleza-Tapia et al., 2018; Wang et al., 2019, 2020a; Du et al., 2020). Here, TRPV1 is linked to depressive disorder.