Subsequently, the analysis of immune cell infiltration under various immune checkpoint patterns suggested ICGcluster A was rich in adaptive immune cells (activated B cells, activated CD4+/CD8+ T cells, gamma delta T cells, regulatory T cells, T follicular helper cells, type 1/2/17 T helper cells) and some tumor-related innate immune cells (activated dendritic cells, NK cells, CD56 bright NK cells, CD56 dim NK cells, macrophages, MDSC) (Figure 3D). Here, CD8A is linked to neoplasm.