In addition, some studies have found that METTL3/14 expression in the β cells of T2D patients and diabetic mice is decreased, leading to decreased β cell proliferation and impaired insulin secretion by reducing the m6A modification levels of several transcripts related to cell cycle progression, insulin secretion, and insulin/IGF1-AKT-PDX1 pathway (De Jesus et al., 2019; Wang et al., 2020d). This evidence concerns the gene INS and type 2 diabetes mellitus.