YTHDF1 deficiency regulates the transformation efficiency of cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 4 (CDK4), and cyclin D1 (CCND1) through the Keap1-Nrf2-AKR1C1 pathway to inhibit tumour cell proliferation and xenograft tumorigenesis. The gene discussed is CDK2; the disease is neoplasm.