Thus, in this study, a putative miRNA-mRNA regulatory network of DGBXD acting on IPF was proposed, which includes miR-654-3p-PKIA/ADRB1, miR-493-5p-FOS/OLR1, miR-410-3p/miR-495-3p-VEGFA, and miR-493-3p-MAP2 of upregulated miRNA and downregulated gene modulatory network; miR-203a-3p-TOP2A/MMP1/TP63 and miR-338-3p-MMP2/HIF1A/MMP9 of downregulated miRNA and upregulated gene modulatory network. Here, PKIA is linked to idiopathic pulmonary fibrosis.