SPARC and neuroblastoma: For instance, the overexpression of secreted protein acidic and rich in cysteine (SPARC) reduces vascular endothelial growth factor-A (VEGFA) expression in NB1691 neuroblastoma cells via miR-410; in addition, the overexpression of SPARC combined with miR-410 was demonstrated to be more effective at alleviating angiogenesis, whereas the administration of miR-410 blockers attenuated the suppression of VEGFA mediated by SPARC in NB1691 cells [94].