NFE2L2 and cancer: Nuclear factor erythroid-2-related factor 2 (NRF2) plays as the primary regulator of cytoprotective response to the endogenous and exogenous stresses; thus essential to prevent the cancer initiation and progression, either in healthy or malignant tissues.13 This pathway was showed to induce ETBR transcription and reduce ET-1 expression in endothelial cells isolated from human or rodent.14