KLK4 and in situ carcinoma: Cisplatin (CIS) is a platinum-based chemotherapeutic drug that induces cytotoxicity through the kallikrein-kinin system and leads to inflammatory and oxidative stress.15 However, CIS has serious side effects such as hepatotoxicity,16 nephrotoxicity,17 ototoxicity18 and neurotoxicity.18 Therefore, studies to improve chemotherapy efficacy while reducing their side effects are rigorous to be able better to control the metastasis and progressivity of ovarian cancer.