TSG101 and cancer: In the midbody, CEP55 recruits endosomal sorting complex required for transport machinery (ESCRT) components by direct interaction with ESCRT-I subunit members TSG101 (tumor susceptibility gene 101) and ALIX (ALG-2-interacting protein X) through the EABR domain, then leads to the recruitment of ESCRT-III for completing cytokinesis.7,8 Overexpression has been found in various tumors related to poor prognosis in cancer patients.