ESR1 and COVID-19: Several drugs like remdesivir a monophosphate prodrug used for potential treatment of Ebola virus was approved by FDA under emergency situations in severely ill COVID-19 patients, mefuparib (CVL218) a poly (ADPribose) polymerase1 inhibitor shows antiviral activity against SARS-COV-2, toremifene selective estrogen receptor modulator l used in breast cancer also had the ability to block the interactions of virus in MERS, SARS and inhibits the non-structural proteins of SARS-COV-2.