They utilized synthetic RNA oligonucleotides (mimicking miR-143 precursors) for neutralizing K-Ras mRNA in colorectal cancer cells and indicated that the proliferative potential of “Lovo” colorectal adenocarcinoma cells was lowered.36 Inhibitory effect of miR-143 expression and its downstream target (C-Myc) has been described previously in colorectal cancer37 and B-cell lymphoma.38 In addition to the oligonucleotide mimics, vectors through the increased expression of the target miRNA are introduced for miRNA restoration. The gene discussed is KRAS; the disease is colorectal adenocarcinoma.