They utilized synthetic RNA oligonucleotides (mimicking miR-143 precursors) for neutralizing K-Ras mRNA in colorectal cancer cells and indicated that the proliferative potential of “Lovo” colorectal adenocarcinoma cells was lowered.36 Inhibitory effect of miR-143 expression and its downstream target (C-Myc) has been described previously in colorectal cancer37 and B-cell lymphoma.38 In addition to the oligonucleotide mimics, vectors through the increased expression of the target miRNA are introduced for miRNA restoration. This evidence concerns the gene KRAS and colorectal cancer.