Huang et al indicated that miR-143 and miR-145 have central roles in modulating bone metastasis of prostate cancer cells via inhibiting some cancer markers such as C-Myc, CD133, Klf4, CD44 and Oct4.40 Overexpression of miR-143 has been reported to block the metastasis of pancreatic cancer via decreasing the MMP9 protein.41 Last but not least, cell migration was significantly declined after miR-143 introduction in our study. This evidence concerns the gene MMP9 and Familial prostate cancer.