TNS1 and chronic kidney disease: And in conditions of CKD, the expression of cardiospecific Tns in skeletal muscles is noted (Ricchiuti and Apple, 1999), which, according to some authors, can lead to an increase in serum concentrations of cardiospecific Tns in patients with CKD (Ricchiuti et al., 1998; Ricchiuti and Apple, 1999).