With pronounced drops in filtration rate (for example, with CKD or a decrease in blood pressure), the molecules of cardiospecific Tns will not be filtered (removed) from the bloodstream into the urine, but will accumulate in the blood, which will lead to an increase in the half-life of cardiospecific Tns and prolongation of the diagnostic window (De Zoysa, 2004; Dubin et al., 2013; Di Lullo et al., 2015). The gene discussed is TNS1; the disease is chronic kidney disease.