In line with these modeling results, it has been reported that the reduction in CD59 contributes more to PNH pathogenesis than DAF as there are patients with DAF deficiency but normal CD59 expression who do not have clinically evident hemolytic disease (Wilcox et al., 1991; DeZern and Brodsky, 2015). The gene discussed is CD59; the disease is paroxysmal nocturnal hemoglobinuria.