Modulation of alternative pathway proteins C3, FB, FD, C3b, C3bB, and C3-convertase also reduces the complement fragments C3a (Figure 9A), iC3b, and Ba (data not shown); however, it may not be important for PNH disease as the levels of these inflammatory mediators were not predicted to be elevated in comparison to healthy control. This evidence concerns the gene ELP1 and paroxysmal nocturnal hemoglobinuria.