GSDME and cancer: These data demonstrate that GSDME, not GSDMD, is responsible for the pyroptosis in GC cells induced by SIM, corroborating the previous reports that GSDMD-dependent pyroptosis occurs mainly in non-cancerous cells (Ding et al., 2021; Han et al., 2021; Shi et al., 2021) and GSDME-dependent pyroptosis in cancer cells (Cai et al., 2021; Li et al., 2021; Shangguan et al., 2021).