In cisplatin-induced AKI, PPARα ligand Wy-14643 (WY) prevented cisplatin-induced reduction of mRNA levels and the enzyme activity of mitochondrial medium chain acyl-CoA dehydrogenase (MCAD), and rescued MCAD-mediated FAO to ameliorated acute tubular necrosis (Li et al., 2004). The gene discussed is PPARA; the disease is acute kidney injury.