TLR4 and irritable bowel syndrome: Another multicohort bioinformatics study analyzed mixed patients with IBD who showed nonresponse; nine hub genes (TLR4, TLR2, TLR1, TLR8, CCR1, CD86, CCL4, HCK, and FCGR2A) were identified, and the pathway enrichment highlighted the interaction between the TLR pathway and FcγR signaling.