Another multicohort bioinformatics study analyzed mixed patients with IBD who showed nonresponse; nine hub genes (TLR4, TLR2, TLR1, TLR8, CCR1, CD86, CCL4, HCK, and FCGR2A) were identified, and the pathway enrichment highlighted the interaction between the TLR pathway and FcγR signaling. Here, TLR2 is linked to irritable bowel syndrome.