A previous study reported that STAT3 directly participated in the activation and transdifferentiation of HSC in response to TGFβ and subsequent hepatic fibrosis (Tang et al., 2017), it also showed that the JAK1/STAT3 signaling pathway played an important role in HSC activation and liver fibrosis (Tang et al., 2017). This evidence concerns the gene TGFB1 and Hepatic fibrosis.