A previous study reported that STAT3 directly participated in the activation and transdifferentiation of HSC in response to TGFβ and subsequent hepatic fibrosis (Tang et al., 2017), it also showed that the JAK1/STAT3 signaling pathway played an important role in HSC activation and liver fibrosis (Tang et al., 2017). The gene discussed is STAT3; the disease is Hepatic fibrosis.