Apart from the four known target proteins and six known differential gene proteins regulated by LS, there are 10 other potential target proteins (PIK3CA, JAK3, JAK1, JAK2, MTOR, CCND1, MCL1, CREBBP, PDGFRA and TYK2) that have not been reported to be related to LS. Here, JAK3 is linked to Leigh syndrome.